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It also depends on your target's immunity (e.g. in pvp vs an assassin or a shaman with immunity buff, there is no amount of hit rating that can help you I guess :p).

And additionally you may have...

Is the Penetration stat able to lower the opponent's Deflection to negative values (increasing the damage against a non-shielded or one-shielded target for example) ?

Some modifications to the debuff list (addenda in bold, modifications in italic) :

PHYSICAL RUIN:
Conqueror (Breach), Guardian (Guard Destroyer) - this one has a 20s duration instead of the usual...

IIRC :
Tapping sideways increases your immunity by 10%, and your evade by 2% per point invested on some pvp general bronze perk.
Tapping backwards increases your evade by 25% (the buff is shorter...